Validating the genomic signature of pediatric septic shock
Clinical manifestations of sepsis are derived from systemic inflammatory response syndrome.Age‐related defects in immunity are shown by changes in cellular and humoral immunity.Immune defects associated with age are shown by changes in cellular and humoral immunity .Aging is associated with an increase in memory T‐cell  repertoire and in the responses of types 1 and 2 [11, 12].According to the new criteria for the diagnosis of sepsis, organ dysfunction promoted by the disease must be considered .
Factors that contribute to this increase include defects in the integrity of epithelial barriers, dysfunction in the cough reflex, changes in level of consciousness, immobility, comorbidities, presence of invasive medical devices, a decrease in physiological reserves, endocrine disorders, and malnutrition [8, 9].Figure 1 illustrates the stages of evolution of sepsis using SIRS as the standard diagnosis.Recently, the Journal of the American Medical Association (JAMA) published the “Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis‐3).” This is the most recent international consensus on diagnostic criteria for sepsis and septic shock.Medicine » Critical Care and Emergency Medicine » "Sepsis", book edited by Vijay Kumar, ISBN 978-9-4, Print ISBN 978-9-7, Published: August 23, 2017 under CC BY 3.0 license. Sepsis is a complex condition that is initiated by infection.The incidence of sepsis and its severity are higher at an older age (mean age of approximately 65 years).
B cells gradually decrease with age, while the production of immunoglobulin increases .